The ACE gene I/D polymorphism is not associated with the blood pressure and cardiovascular benefits of ACE inhibition
Identifieur interne : 00B023 ( Main/Exploration ); précédent : 00B022; suivant : 00B024The ACE gene I/D polymorphism is not associated with the blood pressure and cardiovascular benefits of ACE inhibition
Auteurs : Stephen B. Harrap [Australie] ; Christophe Tzourio [France] ; Francois Cambien [France] ; Odette Poirier [France] ; Segolene Raoux [France] ; John Chalmers [Australie] ; Neil Chapman [Australie] ; Samuel Colman [Australie] ; Solenn Leguennec [France] ; Stephen Macmahon [Australie] ; Bruce Neal [Australie] ; Takayoshi Ohkubo [Australie] ; Mark Woodward [Australie]Source :
- Hypertension : (Dallas, Tex. 1979) [ 0194-911X ] ; 2003.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Homme.
English descriptors
- KwdEn :
Abstract
The insertion/deletion (I/D) polymorphism of the angiotensin-converting enzyme (ACE) gene might have consequences for the risks of vascular diseases. We examined the ACE genotype and the effects of a perindopril-based blood pressure-lowering regimen on macrovascular events, dementia, and cognitive decline among hypertensive and nonhypertensive patients with a history of cerebrovascular disease. ACE I/D genotypes were measured in 5688 of 6105 individuals with previous stroke or transient ischemic attack who participated in the PROGRESS trial. The DD genotype was significantly (P<0.0001) less frequent in Asian subjects (Chinese and Japanese, 14.7%) than in non-Asian subjects (32.0%). Controlling for racial background, there were no associations between ACE genotypes and cerebrovascular disease history or cardiovascular risk factors, including baseline blood pressure. The ACE genotype was not associated with the long-term risks of stroke, cardiac events, mortality, dementia, or cognitive decline; neither did the ACE genotype predict the blood pressure reduction associated with the use of the ACE inhibitor perindopril. Similarly, there was no evidence that the ACE genotype modified the relative benefits of ACE inhibitor-based therapy over placebo. This study provides no evidence that in patients with cerebrovascular disease, knowledge of ACE genotype is useful for predicting either the risk of disease or the benefits of perindopril-based blood pressure-lowering treatment.
Affiliations:
- Australie, France
- Nouvelle-Galles du Sud, Victoria (État), Île-de-France
- Melbourne, Paris, Sydney
- Université de Melbourne, Université de Sydney
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B." last="Harrap">Stephen B. Harrap</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Department of Physiology, University of Melbourne</s1><s2>Melbourne</s2><s3>AUS</s3><sZ>1 aut.</sZ></inist:fA14><country>Australie</country><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region><settlement type="city">Melbourne</settlement></placeName><orgName type="university">Université de Melbourne</orgName></affiliation></author><author><name sortKey="Tzourio, Christophe" sort="Tzourio, Christophe" uniqKey="Tzourio C" first="Christophe" last="Tzourio">Christophe Tzourio</name><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>National Institute of Health and Medical Research, INSERM U360, Hopital de la Salpetriere</s1><s2>Paris</s2><s3>FRA</s3><sZ>2 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Cambien, Francois" sort="Cambien, Francois" uniqKey="Cambien F" first="Francois" last="Cambien">Francois Cambien</name><affiliation wicri:level="3"><inist:fA14 i1="03"><s1>INSERM U525, Faculté de Medecine</s1><s2>Paris</s2><s3>FRA</s3><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Poirier, Odette" sort="Poirier, Odette" uniqKey="Poirier O" first="Odette" last="Poirier">Odette Poirier</name><affiliation wicri:level="3"><inist:fA14 i1="03"><s1>INSERM U525, Faculté de Medecine</s1><s2>Paris</s2><s3>FRA</s3><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Raoux, Segolene" sort="Raoux, Segolene" uniqKey="Raoux S" first="Segolene" last="Raoux">Segolene Raoux</name><affiliation wicri:level="3"><inist:fA14 i1="03"><s1>INSERM U525, Faculté de Medecine</s1><s2>Paris</s2><s3>FRA</s3><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Chalmers, John" sort="Chalmers, John" uniqKey="Chalmers J" first="John" last="Chalmers">John Chalmers</name><affiliation wicri:level="4"><inist:fA14 i1="04"><s1>Institute for International Health, University of Sydney</s1><s2>Sydney</s2><s3>AUS</s3><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ></inist:fA14><country>Australie</country><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region><settlement type="city">Sydney</settlement></placeName><orgName type="university">Université de Sydney</orgName></affiliation></author><author><name sortKey="Chapman, Neil" sort="Chapman, Neil" uniqKey="Chapman N" first="Neil" last="Chapman">Neil Chapman</name><affiliation wicri:level="4"><inist:fA14 i1="04"><s1>Institute for International Health, University of Sydney</s1><s2>Sydney</s2><s3>AUS</s3><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ></inist:fA14><country>Australie</country><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region><settlement type="city">Sydney</settlement></placeName><orgName type="university">Université de Sydney</orgName></affiliation></author><author><name sortKey="Colman, Samuel" sort="Colman, Samuel" uniqKey="Colman S" first="Samuel" last="Colman">Samuel Colman</name><affiliation wicri:level="4"><inist:fA14 i1="04"><s1>Institute for International Health, University of Sydney</s1><s2>Sydney</s2><s3>AUS</s3><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ></inist:fA14><country>Australie</country><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region><settlement type="city">Sydney</settlement></placeName><orgName type="university">Université de Sydney</orgName></affiliation></author><author><name sortKey="Leguennec, Solenn" sort="Leguennec, Solenn" uniqKey="Leguennec S" first="Solenn" last="Leguennec">Solenn Leguennec</name><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>National Institute of Health and Medical Research, INSERM U360, Hopital de la Salpetriere</s1><s2>Paris</s2><s3>FRA</s3><sZ>2 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Macmahon, Stephen" sort="Macmahon, Stephen" uniqKey="Macmahon S" first="Stephen" last="Macmahon">Stephen Macmahon</name><affiliation wicri:level="4"><inist:fA14 i1="04"><s1>Institute for International Health, University of Sydney</s1><s2>Sydney</s2><s3>AUS</s3><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ></inist:fA14><country>Australie</country><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region><settlement type="city">Sydney</settlement></placeName><orgName type="university">Université de Sydney</orgName></affiliation></author><author><name sortKey="Neal, Bruce" sort="Neal, Bruce" uniqKey="Neal B" first="Bruce" last="Neal">Bruce Neal</name><affiliation wicri:level="4"><inist:fA14 i1="04"><s1>Institute for International Health, University of Sydney</s1><s2>Sydney</s2><s3>AUS</s3><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ></inist:fA14><country>Australie</country><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region><settlement type="city">Sydney</settlement></placeName><orgName type="university">Université de Sydney</orgName></affiliation></author><author><name sortKey="Ohkubo, Takayoshi" sort="Ohkubo, Takayoshi" uniqKey="Ohkubo T" first="Takayoshi" last="Ohkubo">Takayoshi Ohkubo</name><affiliation wicri:level="4"><inist:fA14 i1="04"><s1>Institute for International Health, University of Sydney</s1><s2>Sydney</s2><s3>AUS</s3><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ></inist:fA14><country>Australie</country><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region><settlement type="city">Sydney</settlement></placeName><orgName type="university">Université de Sydney</orgName></affiliation></author><author><name sortKey="Woodward, Mark" sort="Woodward, Mark" uniqKey="Woodward M" first="Mark" last="Woodward">Mark Woodward</name><affiliation wicri:level="4"><inist:fA14 i1="04"><s1>Institute for International Health, University of Sydney</s1><s2>Sydney</s2><s3>AUS</s3><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ></inist:fA14><country>Australie</country><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region><settlement type="city">Sydney</settlement></placeName><orgName type="university">Université de Sydney</orgName></affiliation></author></analytic><series><title level="j" type="main">Hypertension : (Dallas, Tex. 1979)</title><title level="j" type="abbreviated">Hypertension : (Dallas Tex., 1979)</title><idno type="ISSN">0194-911X</idno><imprint><date when="2003">2003</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Hypertension : (Dallas, Tex. 1979)</title><title level="j" type="abbreviated">Hypertension : (Dallas Tex., 1979)</title><idno type="ISSN">0194-911X</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Antihypertensive agent</term><term>Arterial pressure</term><term>Chemotherapy</term><term>Controlled therapeutic trial</term><term>Coronary heart disease</term><term>Enzyme inhibitor</term><term>Gene</term><term>Genetic determinism</term><term>Human</term><term>Peptidyl-dipeptidase A</term><term>Perindopril</term><term>Polymorphism</term><term>Prognosis</term><term>Stroke</term><term>Treatment</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Cardiopathie coronaire</term><term>Peptidyl-dipeptidase A</term><term>Gène</term><term>Polymorphisme</term><term>Pression artérielle</term><term>Essai thérapeutique contrôlé</term><term>Périndopril</term><term>Inhibiteur enzyme</term><term>Accident cérébrovasculaire</term><term>Chimiothérapie</term><term>Traitement</term><term>Pronostic</term><term>Déterminisme génétique</term><term>Homme</term><term>Antihypertenseur</term><term>Angiotensin converting enzyme</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Homme</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The insertion/deletion (I/D) polymorphism of the angiotensin-converting enzyme (ACE) gene might have consequences for the risks of vascular diseases. We examined the ACE genotype and the effects of a perindopril-based blood pressure-lowering regimen on macrovascular events, dementia, and cognitive decline among hypertensive and nonhypertensive patients with a history of cerebrovascular disease. ACE I/D genotypes were measured in 5688 of 6105 individuals with previous stroke or transient ischemic attack who participated in the PROGRESS trial. The DD genotype was significantly (P<0.0001) less frequent in Asian subjects (Chinese and Japanese, 14.7%) than in non-Asian subjects (32.0%). Controlling for racial background, there were no associations between ACE genotypes and cerebrovascular disease history or cardiovascular risk factors, including baseline blood pressure. The ACE genotype was not associated with the long-term risks of stroke, cardiac events, mortality, dementia, or cognitive decline; neither did the ACE genotype predict the blood pressure reduction associated with the use of the ACE inhibitor perindopril. Similarly, there was no evidence that the ACE genotype modified the relative benefits of ACE inhibitor-based therapy over placebo. This study provides no evidence that in patients with cerebrovascular disease, knowledge of ACE genotype is useful for predicting either the risk of disease or the benefits of perindopril-based blood pressure-lowering treatment.</div></front></TEI><affiliations><list><country><li>Australie</li><li>France</li></country><region><li>Nouvelle-Galles du Sud</li><li>Victoria (État)</li><li>Île-de-France</li></region><settlement><li>Melbourne</li><li>Paris</li><li>Sydney</li></settlement><orgName><li>Université de Melbourne</li><li>Université de Sydney</li></orgName></list><tree><country name="Australie"><region name="Victoria (État)"><name sortKey="Harrap, Stephen B" sort="Harrap, Stephen B" uniqKey="Harrap S" first="Stephen B." last="Harrap">Stephen B. Harrap</name></region><name sortKey="Chalmers, John" sort="Chalmers, John" uniqKey="Chalmers J" first="John" last="Chalmers">John Chalmers</name><name sortKey="Chapman, Neil" sort="Chapman, Neil" uniqKey="Chapman N" first="Neil" last="Chapman">Neil Chapman</name><name sortKey="Colman, Samuel" sort="Colman, Samuel" uniqKey="Colman S" first="Samuel" last="Colman">Samuel Colman</name><name sortKey="Macmahon, Stephen" sort="Macmahon, Stephen" uniqKey="Macmahon S" first="Stephen" last="Macmahon">Stephen Macmahon</name><name sortKey="Neal, Bruce" sort="Neal, Bruce" uniqKey="Neal B" first="Bruce" last="Neal">Bruce Neal</name><name sortKey="Ohkubo, Takayoshi" sort="Ohkubo, Takayoshi" uniqKey="Ohkubo T" first="Takayoshi" last="Ohkubo">Takayoshi Ohkubo</name><name sortKey="Woodward, Mark" sort="Woodward, Mark" uniqKey="Woodward M" first="Mark" last="Woodward">Mark Woodward</name></country><country name="France"><region name="Île-de-France"><name sortKey="Tzourio, Christophe" sort="Tzourio, Christophe" uniqKey="Tzourio C" first="Christophe" last="Tzourio">Christophe Tzourio</name></region><name sortKey="Cambien, Francois" sort="Cambien, Francois" uniqKey="Cambien F" first="Francois" last="Cambien">Francois Cambien</name><name sortKey="Leguennec, Solenn" sort="Leguennec, Solenn" uniqKey="Leguennec S" first="Solenn" last="Leguennec">Solenn Leguennec</name><name sortKey="Poirier, Odette" sort="Poirier, Odette" uniqKey="Poirier O" first="Odette" last="Poirier">Odette Poirier</name><name sortKey="Raoux, Segolene" sort="Raoux, Segolene" uniqKey="Raoux S" first="Segolene" last="Raoux">Segolene Raoux</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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